Journal: Brain Connectivity

Article Title: Nx4 Modulated Resting-State Functional Connectivity Between Amygdala and Prefrontal Cortex in a Placebo-Controlled, Crossover Trial

doi: 10.1089/brain.2021.0189

Figure Lengend Snippet: Study flow for primary end-points 2 and 3 evaluating rsFC without prior stress induction. On both study days, baseline rsfMRI scans were acquired immediately before dosing (RS0) and another rsfMRI about 1-h post-dose (RS1) without any stress-related tasks in between. Participants of the crossover trial received Nx4 on day 1 and placebo on day 2 or vice versa . A total of four rsfMRI scans per participant were performed for primary end-points 2 and 3. Nx4, Neurexan ® ; rsFC, resting-state functional connectivity; rsfMRI, resting-state functional magnetic resonance imaging.

Article Snippet: We analyzed resting-state fMRI (rsfMRI) data collected in the NEURIM trial ( ClinicalTrials.gov identifier: NCT02602275; registered October 28, 2015) whose first primary end-point has been previously published (Herrmann et al., ).

Techniques: Functional Assay, Magnetic Resonance Imaging